发布日期:2018-04-28     浏览次数:次   

课题组网站: https://lwye.xmu.edu.cn/index.htm

博士后 (University of California at Santa Barbara,2009/05-2011/07)
博士后 (The Scripps Research Institute,2008/09-2009/05)
博士 (中科院上海有机所,2003/09-2008/07)
学士 (浙江大学化学系,1999/09-2003/07)

中科院院长优秀奖 (2008), 中科院优秀毕业生 (2008), 上海市自然科学一等奖 (2011), 福建省杰出青年科学基金 (2015), Thieme Chemistry Journals Award (2016), 国家优秀青年科学基金(2016), 990am金沙登录(China)NO.1部青年长江学者 (2017), 福建省青年拔尖人才 (2017),厦门大学“田昭武学科交叉奖”一等奖 (2019),国家杰出青年科学基金 (2021)等。

有机合成方法学:基于炔烃转化的选择性控制与多样性合成; 功能分子合成:生物活性分子、天然产物及药物的合成。


  1. 1. F.-L. Hong, L.-W. Ye,*Transition Metal-Catalyzed Tandem Reactions of Ynamides for Divergent N-Heterocycle Synthesis, Acc. Chem. Res. 2020, 53, 2003. (invited review paper on the ynamide chemistry; selected as ESI highly cited papers)

  2. 2. Y.-B. Chen, P.-C. Qian, L.-W. Ye,*Brønsted Acid-Mediated Reactions of Ynamides, Chem. Soc. Rev. 2020, 49, 8897. (invited review paper on the ynamide chemistry)

  3. 3. L.-W. Ye,*X.-Q. Zhu, R. L. Sahani, Y. Xu, P.-C. Qian, R.-S. Liu,* Nitrene Transfer and Carbene Transfer in Gold Catalysis, Chem. Rev. 2021, 121, 9039. (invited review paper on the metal carbene chemistry)

  4. 4. Y.-Q. Zhang,† Y.-B. Chen,† J.-R. Liu, S.-Q. Wu, X.-Y. Fan, Z.-X. Zhang, X. Hong,* L.-W. Ye,*Asymmetric Dearomatization Catalyzed by Chiral Brønsted Acids via Activation of Ynamides, Nat. Chem. 2021, 13, in press.

  5. 5. T.-D. Tan, T.-Y. Zhai, B.-Y. Liu, L. Li, P.-C. Qian,* Q. Sun,* J.-M. Zhou, L.-W. Ye,*Controllable synthesis of benzoxazinones and 2-hydroxy-3-indolinones by visible-light-promoted 5-endo-dig N-radical cyclization cascade, Cell Rep. Phy. Sci. 2021, 2, 100577.

  6. 6. Y.-Q. Zhang, Y.-P. Zhang, Y.-X. Zheng, Z.-Y. Li, L.-W. Ye,*Rapid and Practical Access to Diverse Quindolines by Catalyst-Free and Regioselectivity-Reversed Povarov Reaction, Cell Rep. Phy. Sci. 2021, 2, 100448.

  7. 7. X.-Q. Zhu,† P. Hong,† Y.-X. Zheng, Y.-Y. Zhen, F.-L. Hong, X. Lu,* L.-W. Ye,*Copper-Catalyzed Asymmetric Cyclization of Alkenyl Diynes: Method Development and New Mechanistic Insights, Chem. Sci.2021, 12, 9466.

  8. 8. L.-J. Qi, C.-Y. Shi, P.-F. Chen, L. Li, G. Fang, P.-C. Qian,* C. Deng,* J.-M. Zhou, L.-W. Ye,*Gold-Catalyzed 1,1-Carboalkoxylation of Oxetane-Ynamides via Exocyclic Metal Carbenes: Divergent and Atom-Economical Synthesis of Tricyclic N-Heterocycles, ACS Catal. 2021, 11, 3679.

  9. 9. B.-H. Zhu,† Y.-Q. Zhang,† H.-J. Xu, L. Li, G.-C. Deng, P.-C. Qian,* C. Deng,* L.-W. Ye,*Regio- and Stereoselective Synthesis of Diverse 3,4-Dihydro-2-quinolones through Catalytic Hydrative Cyclization of Imine- and Carbonyl-Ynamides with Water, ACS Catal. 2021, 11, 1706.

  10. 10. C.-Y. Shi, L. Li,* W. Kang, Y.-X. Zheng, L.-W. Ye,*Claisen Rearrangement Triggered by Transition Metal-Catalyzed AlkyneAlkoxylation, Coord. Chem. Rev. 2021, 446, 214131. (invited review paper dedicated to the 100th anniversary of Xiamen University)

  11. 11. T.-D. Tan, Z.-S. Wang, P.-C. Qian,* L.-W. Ye,*Radical Reactions of Ynamides, Small Methods2021, 5, 2000673. (invited review paper dedicated to the 100th anniversary of Xiamen University)

  12. 12. F.-L. Hong, Y.-B. Chen, S.-H. Ye, G.-Y. Zhu, X.-Q. Zhu, X. Lu, R.-S. Liu, L.-W. Ye,*Copper-Catalyzed Asymmetric Reaction of Alkenyl Diynes with Styrenes by Formal [3 + 2] Cycloaddition via Cu-Containing All-Carbon 1,3-Dipoles: Access to Chiral Pyrrole-Fused Bridged [2.2.1] Skeletons,J. Am. Chem. Soc.2020, 142, 7618. (Highlighted by: Synfacts, 2020, 16, 818)

  13. 13. Z.-S. Wang, Y.-B. Chen, H.-W. Zhang, Z. Sun, C. Zhu, L.-W. Ye,* Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines, J. Am. Chem. Soc.2020, 142, 3636. (selected as ESI highly cited papers)

  14. 14. X. Liu, Z.-S. Wang, T.-Y. Zhai, C. Luo, Y.-P. Zhang, Y.-B. Chen, C. Deng,* R.-S. Liu, L.-W. Ye,*Copper-Catalyzed Azide-Ynamide Cyclization for Generation of α-Imino Copper Carbenes: Divergent and Enantioselective Access to Polycyclic N-Heterocycles, Angew. Chem. Int. Ed. 2020, 59, 17984.

  15. 15. X.-Q. Zhu, Z.-S. Wang, B.-S. Hou, H.-W. Zhang, C. Deng,* L.-W. Ye,*Zinc-Catalyzed Asymmetric Formal [4+3] Annulation of Isoxazoles with Enynol Ethers by 6π Electrocyclization: Stereoselective Access to 2H-Azepines, Angew. Chem. Int. Ed.2020, 59, 1666. (Featured in Chin. J. Org. Chem.2020, 40, 1074)

  16. 16. T.-D. Tan, L.-W. Ye,*Chiral γ-lactam synthesis via asymmetric C-H amidation,Nat. Catal. 2019, 2, 182.(News & Views)

  17. 17. B. Zhou, Y.-Q. Zhang, K. Zhang, M.-Y. Yang, Y.-B. Chen, Y. Li, Q. Peng,*S.-F. Zhu,* Q.-L. Zhou, L.-W. Ye,*Stereoselective Synthesis of Medium Lactams Enabled by Metal-Free Hydroalkoxylation/Stereospecific [1,3]-Rearrangement,Nat. Commun. 2019, 10, 3234.

  18. 18. F.-L. Hong, Z.-S. Wang, D.-D. Wei, T.-Y. Zhai, G.-C. Deng, X. Lu, R.-S. Liu, L.-W. Ye,*Generation of Donor/Donor Copper Carbenes through Copper-Catalyzed Diyne Cyclization: Enantioselective and Divergent Synthesis of Chiral Polycyclic Pyrroles, J. Am. Chem. Soc.2019, 141, 16961.(Highlighted by: Synfacts, 2020, 16, 62)

  19. 19. Y. Xu, Q. Sun, T.-D. Tan, M.-Y. Yang, P. Yuan, S.-Q. Wu, X. Lu,* X. Hong, L.-W. Ye,*Organocatalytic Enantioselective Conia-Ene-Type Carbocyclization of Ynamide-Cyclohexanones: Regiodivergent Synthesis of Morphans and Normorphans, Angew. Chem. Int. Ed.2019, 58, 16252. (Highlighted by: Synfacts, 2020, 16, 16)

  20. 20. T.-D. Tan, X.-Q. Zhu, H.-Z. Bu, G. Deng, Y.-B. Chen, R.-S. Liu, L.-W. Ye,* Copper-Catalyzed Cascade Cyclization of Indolyl Homopropargyl Amides: Stereospecific Construction of Bridged Aza-[n.2.1] Skeletons, Angew. Chem. Int. Ed.2019, 58, 9632. (Featured in Chin. J. Org. Chem. 2019, 39, 2988)

  21. 21. L. Li, X.-Q. Zhu, Y.-Q. Zhang, H.-Z. Bu, P. Yuan, J. Chen, J. Su, X. Deng, L.-W. Ye,*Metal-Free Alkene Carbooxygenation Following Tandem Intramolecular Alkoxylation/Claisen Rearrangement: Stereocontrolled Access to Bridged [4.2.1] Lactones,Chem. Sci. 2019, 10, 3123.(selected as the paper of “RSC Editors’ Choice”&ESI highly cited papers)

  22. 22. B. Zhou, T.-D. Tan, X.-Q. Zhu, M. Shang, L.-W. Ye,*Reversal of Regioselectivity in Ynamide Chemistry,ACS Catal.2019, 9, 6393. (selected as ESI highly cited papers)

  23. 23. C. Shu,† C.-Y. Shi,† Q. Sun, B. Zhou, T.-Y. Li, Q. He, X. Lu,* R.-S. Liu, L.-W. Ye,*Generation of Endocyclic Vinyl Carbene Complexes via Gold-Catalyzed Oxidative Cyclization of Terminal Diynes: Towards Naphthoquinones and Carbazolequinones, ACS Catal.2019, 9, 1019.

  24. 24. W.-B. Shen, Q. Sun, L. Li, X. Liu, B. Zhou, J.-Z. Yan, X. Lu,* L.-W. Ye,* Divergent Synthesis of N-Heterocycles via Controllable Cyclization of Azido-Diynes Catalyzed by Copper and Gold, Nat. Commun. 2017, 8, 1748.

  25. 25. B. Zhou, L. Li, X.-Q. Zhu, J.-Z. Yan, Y.-L. Guo, L.-W. Ye,* Yttrium-Catalyzed Tandem Intramolecular Hydroalkoxylation/Claisen Rearrangement: Efficient Synthesis of Medium-Sized Lactams, Angew. Chem. Int. Ed. 2017, 56, 4015. (selected as ESI highly cited papers)

  26. 26. W.-B. Shen,† X.-Y. Xiao,† Q. Sun, B. Zhou, X.-Q. Zhu, J.-Z. Yan, X. Lu,* L.-W. Ye,* Highly Site-Selective Formal [5+2] and [4+2] Annulations of Isoxazoles with Heterosubstituted Alkynes by Platinum Catalysis: Rapid Access to Functionalized 1,3-Oxazepines and 2,5-Dihydropyridines, Angew. Chem. Int. Ed. 2017, 56, 605. (selected as ESI highly cited papers)

  27. 27. L. Li, X.-M. Chen, Z.-S. Wang, B. Zhou, X. Liu, X. Lu,* L.-W. Ye,*Reversal of Regioselectivity in Catalytic Arene-Ynamide Cyclization: Direct Synthesis of Valuable Azepino[4,5-b]indoles and β–Carbolines and DFT Calculations, ACS Catal.2017, 7, 4004.

  28. 28. B. Zhou, Y.-Q. Zhang, X. Liu, L.-W. Ye,*Gold-Catalyzed Intermolecular Reaction of Ynamides with 3-Indolyl Azides via an Unexpected 1,2-Alkyl Migration, Sci. Bull.2017, 62, 1201.

  29. 29. C. Shu, L. Li, T.-D. Tan, D.-Q. Yuan, L.-W. Ye,*Ring Strain Strategy for the Control of Regioselectivity. Gold-Catalyzed Anti-Markovnikov Cycloisomerization Initiated Tandem Reactions of Alkynes, Sci. Bull.2017, 62, 352. (invited review paper and selected as a front cover)

  30. 30. F. Pan,† X.-L. Li,† X.-M. Chen, C. Shu, P.-P. Ruan, C.-H. Shen, X. Lu,* L.-W. Ye,*Catalytic Ynamide Oxidation Strategy for the Preparation of α-Functionalized Amides, ACS Catal.2016, 6, 6055.

  31. 31. C. Shu, Y.-H. Wang, B. Zhou, X.-L. Li, Y.-F. Ping, X. Lu,* L.-W. Ye,* Generation of α-Imino Gold Carbenes through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides, J. Am. Chem. Soc. 2015, 137, 9567. (Highlighted by JACS Homepage; selected as ESI highly cited papers)

  32. 32. L. Li,† B. Zhou,† Y.-H. Wang, C. Shu, Y.-F. Pan, X. Lu,* L.-W. Ye,* Zinc-Catalyzed Tandem Alkyne Oxidation/C−H Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and β-Carbolines, Angew. Chem. Int. Ed. 2015, 54, 8245. (Featured in Chin. J. Org. Chem. 2015, 35, 2019)

  33. 33. A.-H. Zhou, Q. He, C. Shu, Y.-F. Yu, S. Liu, T. Zhao, W. Zhang, X. Lu,* L.-W. Ye,* Atom-Economic Generation of Gold Carbenes: Gold-Catalyzed Formal [3+2] Cycloaddition between Ynamides and Isoxazoles, Chem. Sci. 2015, 6, 1265.(selected as the top 1% of highly cited papers of RSC in 2015-2016& ESI highly cited papers)

  34. 34. L. Li,† C. Shu,† B. Zhou, Y.-F. Yu, X.-Y. Xiao, L.-W. Ye,*Generation of Gold Carbenes in Water: Efficient Intermolecular Trapping of the α-OxoGold Carbenoids by Indoles and Anilines, Chem. Sci.2014, 5, 4057.

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